This Star-Shaped Pill Could Revolutionize the Way We Take Medicine

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Melanie Gonick / MIT

The future may be star-shaped—the future of medication, anyway. Scientists have created a pill that can unfurl and stay in the stomach, releasing malaria medication for weeks. The researchers, who published a report on their progress in the journal Science Translational Medicine, say the same delivery method could someday be used for almost any drug.

Malaria affects more than 200 million people each year. While treatment is available, it must be taken every day for several weeks. Many of the people affected by malaria live in remote or impoverished areas, which can make it extremely difficult for them to get and take their drugs on time. And if the treatment isn’t completed, the parasite will stick around. It’s not that the drug doesn’t work; it’s that people often can’t and don’t take it. Non-adherence—or failing to take a prescription exactly as prescribed, for as long as prescribed—is a major problem worldwide.

But a very exciting alternative is on the horizon. An interdisciplinary team of engineers and doctors invented a futuristic drug-delivery method: a time-release capsule packed with weeks’ worth of treatment.

The capsule is, well, capsule-shaped when swallowed, but it expands into a star or snowflake shape as it makes its way through the digestive tract. Once it’s fully expanded, it stays put, delivering carefully calibrated doses of medication until it breaks down as the joints connecting the arms to the core dissolve and the arms break off. These smaller pieces then pass safely through the digestive tract.

To test their creation, the research team loaded their capsule with a malaria drug called ivermectin and gave it to infected pigs. The pill worked beautifully; not only did it not hurt the pigs or prevent them from eating, but it also successfully released the ivermectin for 10 days.

The team then devised a mathematical model to see how long-acting ivermectin might work in humans. Their results showed that adding the new capsule to other standard treatments significantly increased the likelihood of eliminating malaria in a given population.

The new capsule could improve not only medicine but also medical science and drug testing, says Shiyi Zhang, co-lead author and a postdoctoral researcher at MIT during the study. “It may help doctors and the pharma industry to better evaluate the efficacy of certain drugs, because currently a lot of patients in clinical trials have serious medication adherence problems that will mislead the clinical studies,” he said in a statement.

Co-senior author Robert Langer of MIT believes his team’s technology has potential for all kinds of drugs and diseases. “Until now, oral drugs would almost never last for more than a day,” Langer says. “This really opens the door to ultra-long-lasting oral systems, which could have an effect on all kinds of diseases, such as Alzheimer’s or mental health disorders. There are a lot of exciting things this could someday enable.”


November 16, 2016 – 2:01pm

4 Famous Recipients of the Nansen Passport, the Travel Document Created for Refugees

filed under: History, Lists, travel
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Dreamed up by a former polar explorer, the Nansen passport was the first legal travel document for refugees. Fridtjof Nansen, an adventurer turned Norwegian diplomat, created the document after becoming the League of Nation’s first High Commissioner for Refugees. In 1922, in response to the refugee crisis in Europe, he created the identity document that bore his name. (That same year he won the Nobel Peace Prize.)

The Nansen passport would go on to restore the right of half a million stateless people—displaced by World War I, the Armenian genocide, and the Russian Revolution—to cross borders and prove their identities. Nansen passports, usually renewed for a year at a time, continued to be issued until the 1940s when they were succeeded by the so-called London Travel Document, created after World War II. While most of those who used the Nansen passport were ordinary citizens, it also proved to be a lifesaver for several famous figures.

1. VLADIMIR NABOKOV

Giuseppe Pinovia Wikimedia // Public Domain

 
On December 15, 1921, the Soviet government delivered an order that denaturalized large segments of the expatriate population. Among their number was Vladimir Nabokov, one of almost a million Russians who had left the country after the revolution. Nabokov travelled for years on Nansen passports. He was among many of the culturally minded Russian emigrés who gravitated to Berlin, where he met and married his wife, also from Russia. She, however, was Jewish, and the couple fled Nazi Germany for Paris in 1937. France had received many Russians after the revolution, and Nabokov’s character Colonel Taxovich in Lolita (1955) is often pointed to as an archetype of the exiled Russian in Paris, forced to accept reduced circumstances and importance.

Nabokov’s provisional documents still often caused him trouble. In his memoir, Speak, Memory he calls the Nansen passport “a very inferior document of a sickly green hue. Its holder was little better than a criminal on parole and had to go through most hideous ordeals every time he wished to travel from one country to another, and the smaller the countries the worse the fuss they made.” In his short story, “Conversation Piece, 1945,” Nabokov’s narrator has a Nansen passport, “tattered sea-green,” missing a stamp “rudely refused” by a French consul. In 1940, Nabokov and his wife Vera left France for the United States, where Nabokov became a naturalized citizen in 1945. After the success of Lolita made his fortune, he spent the end of his life living at the foot of the Swiss Alps on Lake Geneva.

2. MARC CHAGALL

Pierre Choumoff via Wikimedia // Public Domain

 
Marc was born Moïse Shagal (sometimes given as Moyshe Segal), to a Hasidic Jewish couple in what is modern-day Belarus. The young painter was initially a supporter of the Bolshevik Revolution and actually worked for the government. However, following ideological disputes with other artists and financial problems, he left in the early 1920s for France. It’s unclear exactly when he passed into statelessness, but he seems to have used Nansen passports after his 1923 move to France and before becoming a French citizen in 1937.

While Chagall eventually did earn French citizenship, he would lose his nationality for a second time in 1941. When the Nazis took power, Chagall and thousands of other Jews in occupied France had their citizenship stripped.

Luckily, Chagall was smuggled out of France by sympathetic Americans and lived out the rest of the war in New York. His French citizenship was restored after WWII, and he returned to France, where he remained until his death in 1985.

3. ROBERT CAPA

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The life of Robert Capa, born Endre Friedmann in 1913, had a wild trajectory. The young Hungarian, already in trouble for his political activity against his own country’s fascist regime, moved to Berlin in his late teens. He lived in Germany until Hitler’s rise to power prompted him to move to France in 1933.

In Paris he met another Jewish refugee, a woman who went by the name Gerda Taro. She inspired his own transformation to Robert Capa, an “American” photographer who had an easier time selling photos to the French press. Together the professional and romantic partners worked to document the Spanish Civil War. Taro was on a solo trip in 1937 when she died in Spain, but Capa went on to cover World War II. He would follow the Allies across North Africa and Europe, including photographing the D-Day landings for LIFE magazine.

After the war, Capa’s life took something of a turn. He occasionally photographed celebrities and dated Ingrid Bergman. While still traveling extensively, he technically moved to the US in 1939, likely on a Nansen passport after his Hungarian citizenship had been revoked as the result of a change in Hungarian law. (He eventually became an American citizen in 1946.) However, he still also pursued work in war zones. He was killed by a landmine in Thai-Binh, in contemporary Vietnam, covering the French Indochina War in 1954. At the time of his death, he was just 40 years old.

4. IGOR STRAVINSKY

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Stravinsky was born in Russia in 1882. The child of two musicians, he was already widely traveled and established as a ballet composer by the outbreak of World War I. Stravinsky composed for the traveling troupe Ballets Russes, a number of whose members would eventually travel on Nansen passports. The dance company premiered his radically unconventional Rite of Spring in Paris in 1913. After the war began, Stravinsky moved his family to Switzerland.

As far as politics back in Russia were concerned, Stravinsky was a monarchist, so he was not rushing to return home. With his acceptance of a Nansen passport in the early 20s, his biographer Richard Taruskin writes, Stravinsky “renounced his Russian nationality.” Stravinsky moved to France and would subsequently become a French citizen in 1934, move to California in 1940, and earn U.S. citizenship in 1945. His first return to the U.S.S.R. was a highly publicized visit in 1962 as the guest of Nikita Khrushchev, but the renowned composer would live out his rest of his life as an American.


November 16, 2016 – 2:00pm

Newsletter Item for (88715): How to Get the Most From a Counteroffer

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How to Get the Most From a Counteroffer

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When you land a new job offer and your current gig comes back to you with more money or a better title, what do you do? Here’s how to get the most from a counteroffer.

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How to Get the Most From a Counteroffer

Newsletter Item for (88648): The Delicious History of the Nation’s Oldest Chinese-American Restaurant

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The Delicious History of America’s Oldest Chinese-American Restaurant

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The Pekin Noodle Parlor in Butte, Montana, which opened its doors to the public in 1911, is the nation’s oldest Chinese-American restaurant. The owner’s son shares the secret to its longevity.

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History
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The Delicious History of the Nation's Oldest Chinese-American Restaurant

Newsletter Item for (88279): 15 Female Mathematicians Whose Accomplishments Add Up

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15 Female Mathematicians Whose Accomplishments Add Up
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Who says women can’t do math? The world-altering contributions of these 15 notable female mathematicians include making hospitals safer, laying the groundwork for the computer, and advancing space flight.

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Math
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15 Female Mathematicians Whose Accomplishments Add Up

‘Post-Truth’ Named Word of the Year By Oxford Dictionaries

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Whether you get your news from television, social media, or the mouths of politicians, the line separating fact and fiction is sometimes hard to pin down. This feels especially accurate in 2016, a year when fake news stories rose to the top of Facebook’s trending feed and presidential candidates were fact-checked mid-debate. It’s fitting then that post-truth, defined as “relating to or denoting circumstances in which objective facts are less influential in shaping public opinion than appeals to emotion and personal belief,” was recently named Word of the Year by Oxford English Dictionaries.

The word isn’t a new invention—according to Oxford, the concept has been around for the past decade or so. But this year the word skyrocketed to prominence in light of Britain’s break from the European Union and the presidential election in the U.S. The word is commonly seen coupled with the word politics in headlines like: “Why the post-truth political era might be around for a while” and “U.S. election campaign marks low in post-truth politics.”

Stephen Colbert touched on a similar concept when he coined the word truthiness in 2005. That word, which means “believing something is true from the gut, or inside; using life experiences of learnings to make something seem true,” earned the title of Merriam-Webster’s Word of the Year in 2006.

Post-truth was chosen from a shortlist of nine other terms considered for the distinction. As you might expect, the pool featured several politically themed entries, including alt-right (an ideological grouping associated with extreme conservative viewpoints), woke (alert to injustice in society), and Brexiteer (a person who is in favor of the UK withdrawing from the European Union). A few of the contenders, like adulting, hygge, and coulrophobia (fear of clowns), fell on the lighter side.


November 16, 2016 – 1:45pm

Americans Wasted 375 Million Paid Vacation Days in the Past Year

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Americans are really bad at ditching their cubicles for a cabana. According to a new survey conducted by online travel firm Expedia, U.S. residents received an average of 15 annual vacation days in the past year, but they only took 12. Collectively, the nation threw away 375 million vacation days.

Expedia’s 2016 Vacation Deprivation Report examined vacation habits among 9424 employed adults in approximately 28 countries around the world. Not surprisingly, the number of paid days off—and how people use them—varied dramatically among workers in North America, South America, Europe, and Asia, with the U.S. lagging behind many nations.

People in Europe, Brazil, and the United Arab Emirates received the most vacation days—and for the most part, they used them. Workers in Finland, France, Spain, the UAE, and Brazil were all provided with 30 days of leave, and took full advantage of their time off. German and Italian residents also received 30 days vacation, and used 28 and 25 of them, respectively. Meanwhile, 25 vacation days were the norm in Switzerland, Sweden, Norway, Denmark, the United Kingdom, and Austria (as was using them).

Workers in North America and Southeast Asia weren’t so lucky. Employees in the U.S., Canada, Mexico, South Korea, and Thailand only received 15 days of vacation.

Wondering which countries took the fewest vacation days? That would be South Korea, where people took only eight of their 15 (the least among all 28 countries) and Japan, where people were given 20 days but used half that amount.

Why aren’t Americans escaping the office for some much-needed R&R? Twenty-two percent of U.S. survey respondents said they felt like they should wait a year or more after accepting a new job before taking a day off; 14 percent felt guilty (6 percent felt so guilty, they skipped out on vacation altogether); and 9 percent said they were worried that their bosses would view them negatively if they utilized all their vacation days. It’s no surprise, then, that 29 percent of Americans said they typically went one year or longer between vacations, and 25 percent of Americans reported feeling “very vacation deprived.”

Many people view vacations as a luxury, but they’re actually a health necessity. Taking time away from work to de-stress can lower your risk for heart attack, make you feel happier and calmer, and help you live longer. Not only that, time off actually makes you better at your job: One survey conducted by accounting firm Ernst & Young found that workers who take more vacation time receive better performance reviews and are less likely to leave the firm. Instead fearing that a vacation will make you seem lazy, uncommitted, or replaceable, view it as a way to recharge and become a more energetic and productive employee.


November 16, 2016 – 1:30pm

Nebraska Senator Moonlights as an Uber Driver

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Cash-strapped millennials aren’t the only ones who understand the value of a side hustle. As CNN reports, Republican senator Ben Sasse, who represents Nebraska, spent last Saturday night working as an Uber driver.

Members of Congress are forbidden from earning any money that isn’t related to their public service, so Sasse wasn’t motivated by financial gains. The politician explained his actions on Twitter, saying he was moonlighting for the rideshare service to show solidarity with Nebraska workers. Sasse’s office described the Uber job as being part of a larger “work tour.” (The money earned will be donated to charity.)

“Senator Sasse does tons of Nebraska work events, from changing tires on semi trucks to feeding cattle at 5 a.m.,” said a spokesperson in a statement quoted by The Guardian. “This work tour was built around the changing and dis-intermediated economy, a subject he talks about frequently.”

As Uber drivers likely know, the Saturday night shift isn’t all fun and games. “Pro-tip: If you throw up in an uber, the surcharge can be substantial,” Sasse tweeted. Still, he was able to find a silver lining, saying “It’s a market incentive to get drivers to agree to Sat.pm work.”

Sasse isn’t the only notable figure to try a rideshare gig on for size. As CNN reports, Elwood Edwards (the man who recorded AOL’s “You’ve Got Mail” greeting) now works as an Uber driver, and basketball player Shaquille O’Neal recently went incognito and picked up passengers for Lyft, as part of the company’s “Undercover Lyft” series.

[h/t CNN]


November 16, 2016 – 1:15pm